Immutep Limited (IMMP) Nasdaq

  • Ecco la 60° Edizione del settimanale "Le opportunità di Borsa" dedicato ai consulenti finanziari ed esperti di borsa.

    Questa settimana abbiamo assistito a nuovi record assoluti in Europa e a Wall Street. Il tutto, dopo una ottava che ha visto il susseguirsi di riunioni di banche centrali. Lunedì la Bank of Japan (BoJ) ha alzato i tassi per la prima volta dal 2007, mettendo fine all’era del costo del denaro negativo e al controllo della curva dei rendimenti. Mercoledì la Federal Reserve (Fed) ha confermato i tassi nel range 5,25%-5,50%, mentre i “dots”, le proiezioni dei funzionari sul costo del denaro, indicano sempre tre tagli nel corso del 2024. Il Fomc ha anche discusso in merito ad un possibile rallentamento del ritmo di riduzione del portafoglio titoli. Ieri la Bank of England (BoE) ha lasciato i tassi di interesse invariati al 5,25%. Per continuare a leggere visita il link

Ciao Luciano, quando puoi dai un occhio a GlycoMimetics, Inc. (GLYC), dici che IMMP potrà avere un comportamento simile ?

Urca bella, dopo provo a leggere qualcosa, no Bruno penso piuttosto ad una candela come quella di dicembre 2020 credo, quando la Bristol annuncio gli studi di fase III utilizzando la proteina Lag3 , il mercato non capì e pensando si riferissero a Immutep gli fecero fare record di volumi circa 200 mil e spin top in area 8
magari gli speculatori potrebbero comunque anticipare qualcosa nel corso del 2023, rimango convinto che il tempo adesso lavora in ns favore e l'unica cosa che mi interessa e non da ora che gli studi proseguano come fatto fino a ora

un abbraccio
 
Urca bella, dopo provo a leggere qualcosa, no Bruno penso piuttosto ad una candela come quella di dicembre 2020 credo, quando la Bristol annuncio gli studi di fase III utilizzando la proteina Lag3 , il mercato non capì e pensando si riferissero a Immutep gli fecero fare record di volumi circa 200 mil e spin top in area 8
magari gli speculatori potrebbero comunque anticipare qualcosa nel corso del 2023, rimango convinto che il tempo adesso lavora in ns favore e l'unica cosa che mi interessa e non da ora che gli studi proseguano come fatto fino a ora

un abbraccio

se ti piace GLYC dai un occhio anche a CFMS
 
Ahead of Immutep Limited's AGM tomorrow, CEO Marc Voigt chatted to Jared Lynch of The Australian yesterday about the strength of the Company's recent efti results in non-small cell lung cancer which were presented at #SITC2022.

From the article:
In the study, the number of lung cancer patients who responded successfully to Merk’s drug Keytruda effectively doubled when used in combination with Immutep’s lead product efti.

The results look promising for Immutep, considering Keytruda is one of the world’s biggest selling medicines, generating $4.8bn in sales in the first quarter of this year. Combined with efti, the hope is to grow those sales, given the significant need to treat patients with non-small cell lung cancer.

Full article: http://bit.ly/3tRo8Jq
#LAG3 #immunotherapy
 
Ciao Antares, calcolando che le azioni sono circa 86 milioni, significherebbe un valore pari a (4.8B : 86M) = 55$? :)
 
No, quello è quanto viene incassato da Keytruda, farmaco di Merck. Il farmaco Etfi di Immutep se somministrato insieme aumenta l'efficacia di quel farmaco.
Ma dubito venga venduto allo stesso prezzo così come non so il dosaggio né mille altri parametri collaterali che non possono semplificarsi nella tua formuletta matematica.
 
21 NOV 2022 | DARMSTADT, GERMANY
Not intended for US-, Canada- or UK-based media

Company aims to launch one new product or indication every 1.5 years on average, bolstered by external innovation
Phase III assets xevinapant and evobrutinib are expected to drive next wave of launches
Focused leadership approach to pipeline enrichment builds on expertise in key biology and therapeutic areas as well as technological capabilities
Darmstadt, Germany, November 21, 2022 – Merck, a leading science and technology company, today shared updates on the company’s healthcare research and development strategy, aimed at doubling R&D productivity. To achieve the goal of introducing one new product or major indication every 1.5 years on average, the company will focus its expertise and capabilities and leverage synergies within the existing pipeline to deliver transformative medicines in Oncology, Neurology and Immunology, augmented by an increased focus on external innovation. The company expects to maintain the output of its internal discovery engine, while more than 50% of future launches will result from external co-development partnerships and strategic in-licensing of assets for further in-house development. The strategy was shared today at the company’s R&D Update Call.

“We are driven by our ambition to accelerate the discovery, development and delivery of innovative medicines to patients with cancer and neuroinflammatory and immune-mediated diseases,” said Danny Bar-Zohar, Global Head of Research & Development and Chief Medical Officer for the Healthcare business sector of Merck. “With a mindset of design simplicity and resource discipline paired with agility of execution, we will speed the generation of high-quality data that will support our efforts to bring forth more medicines for more patients, faster.”

To increase R&D productivity, the company will build on its established expertise in the underlying biology of its focused therapeutic areas of oncology, neurology and immunology and will leverage technological capabilities, particularly its industry-leading antibody-drug conjugate (ADC) technology.

Oncology: Synergistic Approaches to Striking Cancer at Its Core

The company’s oncology research and development strategy centers on cancer DNA while building on existing leadership in key cancer types, including head and neck, urothelial and colorectal cancers. The oncology pipeline is focused on synergistic approaches targeting key pathways involved in cancer cell survival, deploying mechanisms to hit cancer at its core:

Delivering tumor DNA-damaging payloads right to the cancer with cutting-edge ADC technology
Preventing cancer cells from repairing DNA damage, through inhibition of the DNA damage response (DDR)
Restoring sensitivity to apoptosis, the cells’ natural death mechanism, which cancer can inhibit
The lead asset in the oncology pipeline is xevinapant, an investigational first-in-class potent oral small molecule IAP (Inhibitor of Apoptosis Protein) inhibitor being evaluated in the curative setting of locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) - an area that has not seen significant advances in treatment in the past 20 years. Xevinapant, which was in-licensed from Debiopharm in March 2021, builds on the company’s long heritage and extensive expertise in SCCHN. Based on the promising efficacy and safety profile seen in the Phase II trial and the urgent need for new treatments, the company is evaluating xevinapant in two ongoing randomized, double-blind, placebo-controlled Phase III clinical trials with the goal of transforming the standard of care: the TrilynX study (NCT04459715) in patients with unresected LA SCCHN, and the XRay Vision study (NCT05386550) in patients with resected LA SCCHN who are at high risk of relapse and are ineligible for cisplatin. Additional external studies and real-world evidence are expected to elucidate the potential for xevinapant across additional patient segments.

The company’s broad portfolio of selective and potent DDR inhibitors includes several agents under development that directly inhibit DDR pathways required for cancer cell survival. By attacking the inherent genetic instability of cancer cells, these agents have the potential to exploit this weakness and tip the therapeutic balance in difficult-to-treat cancers. The oral ATR (ataxia telangiectasia and Rad3-related) inhibitor M1774, which has been designed as a potentially best-in-class molecule, is the leading DDR asset in the pipeline. Recently presented dose-escalation results showed that M1774 at its recommended dose expansion level showed pharmacologically robust exposure and a favorable safety profile. M1774 has broad potential in combination with other DDR inhibitors and other medicines, and as monotherapy in the right genomic context. The DDR portfolio also includes inhibitors of ATM (ataxia-telangiectasia mutated) and DNA-PK (DNA-dependent protein kinase) and has recently been complemented by a collaboration with Nerviano Medical Sciences with the option for a license agreement on the next-generation selective PARP1 (poly (ADP-ribose) polymerase) inhibitor NMS-293.

Earlier this year, M9140, the first ADC developed using the company’s own technology, advanced into human trials. The ongoing Phase Ia study is assessing M9140 in patients with colorectal cancer. M9140 is an anti-CEACAM5 ADC with a topoisomerase 1 inhibitor (exatecan) payload that has been rationally designed for stability in circulation and superior cancer cell killing activity with a broad therapeutic window. M9140 has synergistic potential with DDR inhibition as well.

Neurology and Immunology: Expansion Building on Strength in Neurology and Immune Biology

In neurology and immunology, Merck aims to expand its Multiple Sclerosis (MS) portfolio with evobrutinib, an investigational, oral, CNS-penetrating, highly selective inhibitor of Bruton’s tyrosine kinase (BTK) with the potential to become a best-in-class treatment option for relapsing multiple sclerosis (RMS). In a Phase II study and follow-up, evobrutinib is the first BTK inhibitor (BTKi) to demonstrate sustained clinical efficacy for people with RMS through three and a half years and impact early biomarkers of ongoing central inflammation that correlate with disease progression, including slowly expanding lesions volume and levels of blood neurofilament light chain protein.

In pre-clinical studies, evobrutinib modulated both B cells and macrophages (in the periphery)/microglia (in the brain). This approach has the potential to positively impact both progression caused by relapses and silent progression occurring independent of relapse. During Phase II, the BTKi dose-finding study demonstrated that BID dosing achieved maximal efficacy with >95% BTK occupancy maintained in 98% of patients before the next dose. The Phase III readout for evobrutinib is expected in Q4 2023.

Merck also seeks to expand in neurology by evaluating the potential of oral cladribine in neurological diseases where inflammation is a primary driver, such as generalized myasthenia gravis.

The company is looking to diversify the pipeline with immunology and accelerate R&D by focusing on targets with proven biology via novel modalities. Key to these efforts is the ongoing Phase II WILLOW study of the TLR7/8 inhibitor enpatoran in cutaneous and systemic lupus erythematosus. Building on expertise in neurology, the company is initiating a proof-of-concept study in neuromuscular conditions dermatomyositis and polymyositis with enpatoran in 2023. These conditions have a high unmet medical need characterized by progressive muscle weakness and show lupus-like patterns of immune activation and TLR7/8 expression.

Patients rely on us. By building on our existing strengths and maximizing synergies within our in-house discovered pipeline and with external assets, we will secure sustainable R&D productivity that leads to innovative medicines for patients in need,” Bar-Zohar added.

To access the presentation and a recording, please visit the company’s website at https://www.merckgroup.com/en/investors/events-and-presentations.html
 
Immutep Limited is pleased to share its Chairman's Address and CEO Presentation which were delivered at the AGM meeting held today. Thank you too all our shareholders who joined the meeting today.

"Immutep continues to hold a leadership position with more LAG-3 product candidates in development than any other biotech or big pharmaceutical company. We have four LAG-3 product candidates including our lead product candidate, eftilagimod alpha (efti) which has a unique mechanism of action in the LAG-3 product landscape. While most LAG-3 products are blocking agents, efti is differentiated as the only LAG-3 product that activates antigen-presenting cells to drive an adaptive immune response to fight cancer. We are also the only LAG-3 pure play company generating a great deal of industry attention," said Chairman, Dr Russell Howard.

Chairman's Address: http://bit.ly/3GE2PTe
CEO Presentation: https://bit.ly/3GE2PTe
#LAG3 #immunotherapy
 
Immutep Limited is pleased to share its Chairman's Address and CEO Presentation which were delivered at the AGM meeting held today. Thank you too all our shareholders who joined the meeting today.

"Immutep continues to hold a leadership position with more LAG-3 product candidates in development than any other biotech or big pharmaceutical company. We have four LAG-3 product candidates including our lead product candidate, eftilagimod alpha (efti) which has a unique mechanism of action in the LAG-3 product landscape. While most LAG-3 products are blocking agents, efti is differentiated as the only LAG-3 product that activates antigen-presenting cells to drive an adaptive immune response to fight cancer. We are also the only LAG-3 pure play company generating a great deal of industry attention," said Chairman, Dr Russell Howard.

Chairman's Address: http://bit.ly/3GE2PTe
CEO Presentation: https://bit.ly/3GE2PTe
#LAG3 #immunotherapy

thank
 
Qualcuno si sta accorgendo che immutep esiste....
 
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La situazione degli oscillatori la rende interessante graficamente...
 
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interessante anche il grafico australiano, con questa resistenza a 0,325

ci vedrei quasi quasi una tazza col manico....
 
In Australia ha chiuso un gap andando ad aprirne un altro.
Negli USA siamo sempre sotto la EMA200. È da un anno che ci sta sotto senza riuscire a tornarci sopra.
 
Indietro